GC376 is in stock now! GC376 (cas# 1416992-39-6) is a representative compound of the dipeptidyl transition state 3CLpro inhibitors, inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM.
PT-2385 (CAS: 1672665-49-4) is in stock now! PT-2385 is a potent ad selective inhibitor of hypoxia inducible factor (HIF-2α) with potential antineoplastic activity. PT-2385 selectively disrupts the heterodimerization of HIF-2α with HIF-1β. Very effective in blocking cancer cell growth, proliferation.
GLPG-1690 , an imidazopyridine derivative, has been found to be a ENPP2 protein inhibitor that could probably be effective as an anti-inflammatory agent and is under Phase II trial against Idiopathic pulmonary fibrosis.
VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 μM) tIt targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 μM) and glucose-regulated protein 78 (Grp78; KD = 80 nM).hat is selective over Hsp90. VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death. It induces the proteasome-dependent degradation of Hsp 90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors.
Herpes virus helicase-primase inhibitor, Amenamevir is available now! Amenamevir, also known as ASP2151, is a herpes virus helicase-primase inhibitor. Amenamevir was approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on Jul 3, 2017 and marketed as Amenalief