Product Name: LM-10
Cat No: I000006
CAS No: 1316695-35-8
Synonyms: LM 10
LM-10(cas 1316695-35-8) is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively).
Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively).
Product Name: Medetomidine
Cat No: I005178
CAS No: 86347-14-0
Molecular Formula: C13H16N2
Molecular Weight: 200.28
Solubility: 10 mM in DMSO
MuseChem is a leading supplier of custom peptide synthesis services. With rich knowledge and expertise in peptide synthesis and proprietary platform technologies, we offer a wide range of peptide synthesis services from bulk API peptides production to complex peptide modifications. We have an experienced team of scientists who are able to choose and optimize the appropriate peptide synthesis method for each peptide, so our peptide synthesis service has a very high success rate. Each peptide comes with a complete quality control package, which includes HPLC and MS Analysis.
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Product Name: Epibrassinolide
Cat No: I004891
CAS No: 78821-43-9
MDL No: MFCD00133310
Synonyms: 22R,23R,24R-2α,3α,22,23-Tetrahydroxy-B-homo-7-oxa-5α-ergostan-6-one; 24-Epibrassinolide
Molecular Formula: C28H48O6
Molecular Weight: 480.68
Solubility: DMSO: ≥ 5 mg/mL
Target: plant growth regulator; Apoptosis inducer
Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth.
Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. DNA is damaged thousands of times during each cell cycle, and that damage must be repaired. BRCA1, BRCA2 and PALB2 are proteins that are important for the repair of double-strand DNA breaks by the error-free homologous recombinational repair, or HRR, pathway. When the gene for either protein is mutated, the change can lead to errors in DNA repair that can eventually cause breast cancer. When subjected to enough damage at one time, the altered gene can cause the death of the cells. Inhibition of PARPs is a promising strategy for targeting cancers with defective DNA-damage repair, including BRCA1 and BRCA2 mutation-associated breast and ovarian cancers. Several PARP inhibitors are currently in trials in the adjuvant, neoadjuvant, and metastatic settings for the treatment of ovarian, BRCA-mutated breast, and other cancers.
Co-Crystal structure of PARP-1 and one of it’s inhibitors