Product Name: Epibrassinolide
Cat No: I004891
CAS No: 78821-43-9
MDL No: MFCD00133310
InChIKey: IXVMHGVQKLDRKH-QHBHMFGVSA-N
Synonyms: 22R,23R,24R-2α,3α,22,23-Tetrahydroxy-B-homo-7-oxa-5α-ergostan-6-one; 24-Epibrassinolide
Molecular Formula: C28H48O6
Molecular Weight: 480.68
Solubility: DMSO: ≥ 5 mg/mL
Target: plant growth regulator; Apoptosis inducer
Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth.
BYL719(cas 1217486-61-7) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, liitle or no effect on PI3Kβ/γ/δ. BYL719 inhibits the proliferation of breast cancer cell lines harboring PIK3CA mutations, correlating with inhibition of various downstream signaling components of the PI3K/Akt pathway.
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