Musechem

Product Name: Epibrassinolide Cat No: I004891 CAS No: 78821-43-9 MDL No: MFCD00133310 InChIKey: IXVMHGVQKLDRKH-QHBHMFGVSA-N Synonyms: 22R,23R,24R-2α,3α,22,23-Tetrahydroxy-B-homo-7-oxa-5α-ergostan-6-one; 24-Epibrassinolide Molecular Formula: C28H48O6 Molecular Weight: 480.68 Solubility: DMSO: ≥ 5 mg/mL Target: plant growth regulator; Apoptosis inducer Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth.

rac-GR24 (cas 76974-79-3) is a potent synthetic strigolactone analog.

Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. DNA is damaged thousands of times during each cell cycle, and that damage must be repaired. BRCA1, BRCA2 and PALB2 are proteins that are important for the repair of double-strand DNA breaks by the error-free homologous recombinational repair, or HRR, pathway. When the gene for either protein is mutated, the change can lead to errors in DNA repair that can eventually cause breast cancer. When subjected to enough damage at one time, the altered gene can cause the death of the cells. Inhibition of PARPs is a promising strategy for targeting cancers with defective DNA-damage repair, including BRCA1 and BRCA2 mutation-associated breast and ovarian cancers. Several PARP inhibitors are currently in trials in the adjuvant, neoadjuvant, and metastatic settings for the treatment of ovarian, BRCA-mutated breast, and other cancers. Co-Crystal structure of PARP-1 and one of it’s inhibitors Cat No....

CAS No: 1637-39-4 Name: trans-Zeatin Cat No: R013637 trans-Zeatin is a member of the plant hormone family known as ‘cytokinins’, which regulate cell division, development, and nutrient processing. The biosynthesis of cytokinins involves isoprenylation of ATP or ADP, with trans-Zeatin being produced by the removal of phosphate and riboside groups from adenine and oxidation by cytochrome P735A. trans-Zeatin evokes its effects through high affinity receptors, including Arabidopsis histidine kinases (AHK). The affinity of trans-zeatin for AHK3, which is important in mediating plant development, has been reported to be 1.3 nM.

CAS No: 7689-03-4 Synonyms: Campathecin Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. IC50 Value: 50 nM(in MDA-MB-231 cell line) Target: topoisomerase Camptothecin (CPT) has recently been undergoing phase I clinical trials. In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks with excitation wavelengths lambdaex of 215, 255 and 365 nm, separately. Camptothecin shows high activity against various tumor cells. Camptothecin was originally isolated from the stem wood of the Camptotheca acuminata tree and was shown to exhibit antileukemic/antitumour activity, and reversibly inhibit Mitochondrial Topo I (nuclear Topo I (topoisomerase I)) by binding to and stabilizing the topoisomerase-DNA covalent complex. Advancing replication forks are believed to interact with these complexes leading to double strand breaks, which is thought to be resp...

Cat No: I005145 CAS No: 857036-77-2 Synonyms: AZD-2171 maleate Cediranib (AZD2171) maleate is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/ ≤ 3 nM, similar activity against c-Kit and PDGFR β , 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR- α , CSF-1R and Flt3.

AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression. AZD3514 binds to the AR ligand binding domain and has selectivity for binding to AR over other nuclear hormone receptors.

SB1317(TG-02) is a novel small molecule potent CDK2/JAK2/FLT3 inhibitor with IC50s of 13/73/56 nM respectively. TG02 is a novel pyrimidine-based multi-kinase inhibitor that inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3. It dose-dependently inhibits signaling pathways downstream of CDKs, JAK2 and FLT3 in cancer cells with the main targets being CDKs. TG02 is anti-proliferative in a broad range of tumor cell lines, inducing G1 cell cycle arrest and apoptosis. In vivo, TG02 exhibits favorable pharmacokinetics after oral dosing in xenograft models and accumulates in tumor tissues, inducing an effective blockade of both CDK and STAT signaling. TG02 induces tumor regression after oral dosing on both daily and intermittent schedules in a murine model of mutant-FLT3 leukemia (MV4-11) and prolongs survival in a disseminated AML model with wild-type FLT3 and JAK2 (HL-60). TG02 is active in various models of leukemia and provide a rationale for the ongoing clinical evaluation of TG02 i...

Bedaquiline , sold under the brand name Sirturo, is a medication used to treat active tuberculosis. It is specifically used to treat multidrug-resistant tuberculosis (MDR-TB) when other treatment cannot be used. It should be used along with at least three other medications for tuberculosis. It is used by mouth.

L-165041 is a phenyloxyacetate PPARδ receptor agonist. It is less potent and PPARδ selective than GW 501516.

RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. http://www.musechem.com/product/I005517/RAF265.html