PARP Inhibitors In Stock!

Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. DNA is damaged thousands of times during each cell cycle, and that damage must be repaired. BRCA1, BRCA2 and PALB2 are proteins that are important for the repair of double-strand DNA breaks by the error-free homologous recombinational repair, or HRR, pathway. When the gene for either protein is mutated, the change can lead to errors in DNA repair that can eventually cause breast cancer. When subjected to enough damage at one time, the altered gene can cause the death of the cells. Inhibition of PARPs is a promising strategy for targeting cancers with defective DNA-damage repair, including BRCA1 and BRCA2 mutation-associated breast and ovarian cancers. Several PARP inhibitors are currently in trials in the adjuvant, neoadjuvant, and metastatic settings for the treatment of ovarian, BRCA-mutated breast, and other cancers.

Co-Crystal structure of PARP-1 and one of it’s inhibitors

	Cat No.：I000230 Cas No.：1038915-60-4 Product Name：MK-4827	Details
	Cat No.：I000231 Cas No.：1038915-64-8 Product Name：MK-4827 hydrochloride	Details
	Cat No.：I000232 Cas No.：1038915-73-9 Product Name：MK-4827 tosylate	Details
	Cat No.：I000270 Cas No.：1048371-03-4 Product Name：UPF 1069	Details
	Cat No.：I000532 Cas No.：1140964-99-3 Product Name：E7449	Details
	Cat No.：I000622 Cas No.：1174043-16-3 Product Name：AZD-2461	Details
	Cat No.：I000775 Cas No.：1207456-00-5 Product Name：BMN-673 8R,9S	Details
	Cat No.：I000776 Cas No.：1207456-01-6 Product Name：BMN-673	Details
	Cat No.：I001056 Cas No.：1262417-51-5 Product Name：NMS-P118	Details
	Cat No.：I002034 Cas No.：160003-66-7 Product Name：BSI-201	Details
	Cat No.：I002961 Cas No.：283173-50-2 Product Name：Rucaparib	Details
	Cat No.：I003166 Cas No.：328543-09-5 Product Name：AG14361	Details
	Cat No.：I003256 Cas No.：344458-15-7 Product Name：PJ34 hydrochloride	Details
	Cat No.：I003257 Cas No.：344458-19-1 Product Name：PJ34	Details
	Cat No.：I003291 Cas No.：3544-24-9 Product Name：INO-1001	Details
	Cat No.：I003606 Cas No.：459868-92-9 Product Name：Rucaparib phosphate	Details
	Cat No.：I004499 Cas No.：664993-53-7 Product Name：JW 55	Details
	Cat No.：I004506 Cas No.：66611-37-8 Product Name：BGP-15	Details
	Cat No.：I004823 Cas No.：763113-22-0 Product Name：Olaparib	Details
	Cat No.：I005438 Cas No.：912444-00-9 Product Name：Veliparib	Details
	Cat No.：I005439 Cas No.：912445-05-7 Product Name：Veliparib dihydrochloride	Details
	Cat No.：I005541 Cas No.：934162-61-5 Product Name：A-966492	Details